PM2.5 exposure inducing ATP alteration links with NLRP3 inflammasome activation.

Fine particulate matter (PM2.5) has been the primary air pollutant and the fourth leading risk factor for disease and death in the world. Exposure to PM2.5 is related to activation of the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome, but the mechanism of PM2.5 affecting the NLRP3 inflammasome is still unclear. Previous studies have shown that PM2.5 can cause alterations in adenosine triphosphate (ATP), and an increase in extracellular ATP and a decrease in intracellular ATP can trigger the activation process of the NLRP3 inflammasome. Therefore, we emphasize that ATP changes may be the central link and key mechanism of PM2.5 exposure that activates the NLRP3 inflammasome. This review briefly elucidates and summarizes how PM2.5 acts on ATP and subsequently further impacts the NLRP3 inflammasome. Investigation of ATP changes due to exposure to PM2.5 may be essential to regulate NLRP3 inflammasome activation and treat inflammation-related diseases such as coronavirus disease 2019 (COVID-19).

Adverse Cardiovascular Effects of Anti-COVID-19 Drugs.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or COVID-19 infection is the cause of the ongoing global pandemic. Mortality from COVID-19 infection is particularly high in patients with cardiovascular diseases. In addition, COVID-19 patients with preexisting cardiovascular comorbidities have a higher risk of death. Main cardiovascular complications of COVID-19 are myocardial infarction, myocarditis, acute myocardial injury, arrhythmias, heart failure, stroke, and venous thromboembolism. Therapeutic interventions in terms of drugs for COVID-19 have many cardiac adverse effects. Here, we review the relative therapeutic efficacy and adverse effects of anti-COVID-19 drugs.

Characteristics of novel coronavirus pneumonia and TCM treatment in Gansu

This article summarized the clinical diagnosis and treatment of novel coronavirus pneumonia (NCP) in Gansu and concluded that NCP has different clinical manifestations and TCM syndromes in different regions and different patient groups. It concluded the characteristics of NCP in Gansu and the features of TCM treatment. It was found that the pathogenesis of this disease was varied, and syndrome differentiation treatment was carried out based on syndrome differentiation of tri-jiao. It concluded that there were changes in NCP, with dampness pathogen throughout the course of the disease. Therefore, it is recommended to pay attention to the treatment of changing syndrome based on conventional treatment.

Exploration of material basis and molecular mechanism for preventing SARS-CoV-2 infection by Fuzheng Biwen prescription based on computer aided drug design

Objective: To systematically study the material basis and molecular mechanism of the prevention of SARS-CoV-2 infection by Fuzheng Biwen Prescription from the perspective of inhibiting the selection of virus infection and regulating the body's immune factors.